This guide will show you how to unlock Combat and Sign Mutations in The Witcher 3 Blood and Wine. You can unlock Mutations in The Witcher 3: Blood and Wine by finding Dr. Moreau’s secret laboratory. This laboratory is located inside Valley of the Nine. It is a part of Turn and Face the Strange quest. This is an optional quest.

To get to the quest, first you need to receive Yennefer’s letter. The letter will contatin the details about Dr. Moreau’s secret laboratory. With this letter, Geralt will find it and complete Turn and Face the Strange. Then Geralt will get access to Blood and Wine Mutations. Only one mutation can be active at a time. Therefore, you need to select the best one that is suitable for you play style. Once you unlock the low level mutations, the high level mutations will be unlocked.

Unlock Combat and Sign Mutations in The Witcher 3 Blood and Wine

Bloodbath – Combat
Requirement: 2 Greater Red Mutagens and 2 Skill Points

Grants +5% bonus damage per sword attack up to a maximum of +250%. The effect finishes upon death.

Deadly Counter – Combat
Requirement: 2 Greater Red Mutagens and 2 Skill Points

Sword attacks deal +25% damage to humans and monsters who are immune to counters. Enemies vulnerable to counters die at once when HP is below 25%.

Magic Sensibilities – Sign
Requirement: 2 Greater Blue Mutagens and 2 Skill Points

Allows Sign abilities to trigger critical hits. Chances of critical are improved with higher sign intensity. Enemies explode when died with critical signs.

Piercing Cold – Sign
Requirement: 2 Greater Blue Mutagens and 2 Skill Points

Provides +25% chance of freezing enemy with Aard sign. Enemies who are frozen and knocked back die instantly.

Adrenaline Rush – Combat and Sign
Requirement: 2 Greater Red Mutagens and 2 Skill Points

This allows you to get +30% sword and sign damage per enemy faced during first 30 seconds of combat.

Conductors of Magic – Combat and Sign
Requirement: 2 Greater Red Mutagens and 2 Skill Points

Witcher, Unique, and Magic swords increase sign damage by 50% to a percentage of sword’s attack value.

Toxic Blood – Alchemy
Requirement: 2 Greater Green Mutagens and 2 Skill Points

While Toxicity is at 0%, enemies get 1.5% additional damage that they deal to you.

Euphoria – Alchemy
Requirement: 2 Greater Green Mutagens and 2 Skill Points

Provides you with +0.75% sword and sign damage for each Toxicity point which stacks at maximum of +75%.

Cat Eyes – Combat and Alchemy
Requirement: 2 Greater Red Mutagens and 2 Skill Points

You get +700% bonus crossbow damage and critical hit chances are increased to 50% which stun and knockdown enemies.

Mutated Skin – Combat and Alchemy
Requirement: 2 Greater Red Mutagens and 2 Skill Points

When on full Adrenaline Point, you receive -15% damage which maximizes at -45% less damage.

Metamorphosis
Requirement: N/A
Landing a critical activates a random decoction effect for 120 seconds which does not increase Toxicity level. Moreover, Witcher Senses allow you to see in dark places.

Second Life
Requirement: N/A
At 0% vitality, Geralt regenerates to 100% health and becomes invulnerable for a short duration. This effect can again be triggered after a three-minute cool-down.